Pimples, i.e. acne, are prevalent in adolescence. For the treatment of acne, local cleansing, medication intervention and physical therapy are available. 1. Local cleansing: If patients do not pay attention to facial cleansing, it may cause sebum to block the pores, which will lead to the symptoms of acne. Therefore, it is necessary to pay more attention to facial cleansing and make-up removal. 2. Pharmacological intervention: patients can use topical adapalene gel, tazarotene and other drugs to promote the skin surface cell renewal, and at the same time combined with benzoyl peroxide, erythromycin ointment, fusidic acid cream and other anti-infective drugs, so as to increase the therapeutic effect. 3. Physical therapy: patients can combine the application of infrared light irradiation and 5-amino ketovaleric acid to reduce inflammation by destroying Propionibacterium acnes through photodynamic effects. After the diagnosis of acne, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the treatment, do not self-medication.