Numbness and a burning sensation in the ankle and foot is a neuropsychiatric symptom in patients with beriberi. Thiamine is a precursor of thiamine pyrophosphate (TPP), an important coenzyme in the decarboxylation of pyruvate and α-ketoglutarate in the tricarboxylic acid cycle and a coenzyme of erythrocyte ketoltransferase. In addition, it is also related to brain cell activity and nerve impulse transmission. Once deficient, it can cause a series of neurological and circulatory symptoms, called beriberi. The following diseases may also be the cause of ankle and foot numbness and burning pain: 1, diarrhea Normal people generally defecate once a day, individuals defecate 2 to 3 times a day or once every 2 to 3 days, the normal nature of the stool, the average weight of the daily discharge of stool is 150 to 200g, containing 60% to 75% water. Diarrhea (diarrhea) is a common symptom, refers to the number of bowel movements significantly more frequent than usual habits, thin stool, increased water, the daily volume of stool more than 200g, or containing undigested food or pus and blood, mucus, diarrhea is often accompanied by a sense of urgency to defecate, anal discomfort, incontinence and other symptoms, diarrhea is divided into two categories: acute and chronic. Acute diarrhea has a rapid onset and lasts for 2 to 3 weeks, while chronic diarrhea refers to recurrent diarrhea that lasts for more than two months or has an interval of 2 to 4 weeks. Diarrhea is a common symptom of digestive system diseases, referring to more frequent bowel movements than usual, loose stools with increased water content, sometimes with increased fat, with indigestible matter, or mixed with pus and blood mucus. Normal people generally defecate once a day, a few people defecate 2 to 3 times a day or once every 2 to 3 days, and the stool is formed and normal, should not be called diarrhea. Diarrhea is often accompanied by symptoms such as urgency of defecation, perianal discomfort and incontinence. Diarrhea is divided into two kinds of acute and chronic, the duration of diarrhea in more than 2 months, or intermittent period in 2 to 4 weeks of recurrent diarrhea called chronic diarrhea. 2, alcoholic liver disease Alcoholic Hepatitis (Alcoholic Hepatitis) is a liver disease caused by long-term heavy alcohol consumption. The initial stage is usually manifested as fatty liver, which can then develop into alcoholic hepatitis, liver fibrosis and liver cirrhosis. The main clinical features are nausea, vomiting, jaundice, enlargement of the liver and painful pressure. The disease can be complicated by liver failure and upper gastrointestinal bleeding. Severe alcohol abuse can induce extensive hepatocyte necrosis and even liver failure. Alcoholic liver disease is one of the common liver diseases in China, which seriously endangers people’s health. In recent years, the proportion of alcoholic liver disease in hospitalized patients with liver disease in the same period has been increasing, from 4.2% in 1991 to 21.3% in 1996; the composition of alcoholic cirrhosis in the cause of liver cirrhosis increased from 10.8% in 1999 to 24.0% in 2003. Typhoid fever (typhoid fever) is an acute intestinal infection caused by S. typhi, characterized by persistent bacteremia and toxemia, proliferative response of the mononuclear phagocyte system, and proliferation, swelling, necrosis and ulcer formation mainly in the lymphoid tissue of the lower ileum as the basic pathological features. Typical clinical manifestations include persistent high fever, systemic neutrophilic and gastrointestinal symptoms, relatively slow pulse, roseola, hepatosplenomegaly, and leukopenia. This disease is also known as enteric fever. However, the clinical manifestations of the disease are mainly due to the dissemination of the pathogen through the blood to the whole organs of the body, but not due to local lesions of the intestine. Intestinal bleeding and intestinal perforation are the most important and serious complications that can occur. 4.Burning pain Burning pain is a severe and persistent burning sensation on the local skin surface caused by incomplete damage to the peripheral nerves. postts first discussed this disease due to trauma in the late 18th century. mitehell established the term “burning pain” in 1972. 5. Malnutrition Malnutrition is a term used to describe a health condition caused by an inadequate or insufficient diet. It usually refers to nutritional deficiencies caused by inadequate intake, malabsorption or excessive nutrient depletion, but may also include overnutrition caused by overeating or excessive intake of specific nutrients. Individuals will become malnourished if they do not consume a healthy diet consisting of the appropriate quantity, type or quality of nutrients over time. Chronic malnutrition may lead to death by starvation. 6, intestinal knot Most of the intestinal tract dysfunction due to excessive anger after eating cold and hard food, resulting in intestinal obstruction, mostly functional intestinal obstruction. It is one of the common diseases of the gastrointestinal tract. In recent years, with the increase in population mobility and the AIDS epidemic, the number of cases of intestinal tuberculosis has also increased, with a predominance of young and middle-aged people, with a male to female ratio of about 3:1, usually secondary to extra-intestinal tuberculosis, especially bacillary tuberculosis, and a few primary to the intestine.