Numbness and a burning sensation in the ankle and foot is a neuropsychiatric symptom in patients with beriberi. Thiamine is a precursor of thiamine pyrophosphate (TPP), an important coenzyme in the decarboxylation of pyruvate and α-ketoglutarate in the tricarboxylic acid cycle and a coenzyme of erythrocyte ketoltransferase. In addition, it is also related to brain cell activity and nerve impulse transmission. Once deficient, it can cause a series of neurological and circulatory symptoms, called beriberi. It is mainly based on the history of nutritional deficiency and clinical manifestations. The diagnosis of peripheral neuritis can be determined by the following methods: 1. squatting test, when the patient takes a squatting position, he feels pain in the calf and has difficulty in standing up, and often uses second-hand support for the knee to help stand up; 2. pain when the gastrocnemius muscle is squeezed; 3. decreased tactile and pain sensation in the dorsum of the foot, ankle, and lower calf; 4. ankle and knee reflexes are abnormal, mostly diminished or absent. The diagnosis of fulminant pedal heart disease is based on: 1. history of vitamin B1 nutritional deficiency for more than 3 months and signs of peripheral neuritis; 2. acute onset of high output heart failure with irritability; 3. enlarged heart with regular rhythm and no other etiology to be found; 4. immediate therapeutic test for suspected cases, the symptoms of this disease improve rapidly after treatment.