If a patient has chest tightness and pain and has nausea, the following causes should be considered: First, consider cardiogenic diseases, such as coronary heart disease unstable angina, or acute myocarditis, acute pericarditis, infective endocarditis, arrhythmia caused by various factors, heart failure, there will be coronary artery ischemia, stenosis, spasm, at this time, it will cause chest tightness, shortness of breath, accompanied by nausea, acid reflux, heartburn symptoms. Second, if the patient has obvious digestive system diseases, such as acute gastroenteritis, cholecystitis, pancreatitis, peritonitis, these cases will also trigger the visceral involvement-like pain of chest tightness, accompanied by clinical manifestations of nausea, vomiting, acid reflux and heartburn. Third, various factors that lead to poisoning, such as food poisoning, drug poisoning and other cases, will also have this clinical symptoms and reactions.