There is no clear definition of fire in Chinese and Western medicine. According to Chinese medicine, there is a difference between deficiency and reality of fire, both of which can lead to blisters on the mouth. It is not recommended to puncture them, which may lead to infection or more blisters on the affected area. Medications such as Huanglian Shangqing Pill and Gui Shao Di Huang Pill can be taken and should be used under medical supervision. Solid fire refers to the solid heat syndrome caused by the internal exuberance of fire-heat. Huanglian Shangqing Pill can be used to dissipate wind and clear heat, diarrhea fire and relieve pain. This formula is mainly used to treat toothache, mouth and tongue sores, sore throat and other conditions. Adverse effects are not clear. It is contraindicated in patients with deficiency and coldness of the spleen and stomach (spleen and stomach weak and cold). It is contraindicated for pregnant women. It is not advisable to take tonic Chinese medicine at the same time while taking the medicine. Deficiency fire refers to the evidence of yin deficiency and fire exuberance (deficiency of yin and essence in the body, resulting in hyperactivity of deficiency fire). This formula can be used to nourish the liver and kidney, tonify the Yin and blood, and clear the deficiency heat. This formula treats deficiency of liver and kidney, deficiency of yin and blood, dizziness, tinnitus, dryness of the throat, and afternoon hot flashes (a burst of fever). Adverse effects are not clear, avoid indigestible food; not suitable for patients with fever and cold. When discomfort occurs, it should be promptly consulted and treated under the guidance of a doctor, and should not be used on its own or with acupuncture.