Newborns always hiccups may be physiological, such as underdevelopment, gastric distension, etc., but also may be related to gastric tube reflux, congenital heart disease and other pathologic factors. 1. Physiological factors (1) Imperfect development: because the newborn’s diaphragm and digestive function are not well developed, daily eating is slightly stimulated, for example, cold, eating too full, etc. will cause hiccups. (2) Gastric distension: newborns eat too fast, inhale too much air or eat too much, which causes gastric distension and expansion, compressing the diaphragm, thus causing diaphragmatic spasm and hiccups. (3) Vagus nerve stimulation: daily not keep warm, eat cold food, cold stimulation, resulting in decreased excitability of the sympathetic nervous system, vagus nerve hyperreflexia, thus causing hiccups. 2. Pathological factors (1) Gastrointestinal reflux disease: because the food in the stomach refluxes to the esophagus, when staying in the esophagus for a long time, it will cause damage to the esophageal mucosa leading to inflammation, and at the same time pass through the esophageal wall affecting the mediastinum, which will cause hiccups, vomiting and other symptoms. (2) congenital heart disease: congenital heart disease symptoms are based on different shunt direction will have different symptoms, newborns show feeding difficulties, hiccups, choking and other symptoms. If the newborn always hiccups, there are other symptoms, it is recommended to go to the hospital to clarify the cause of the disease, and then give targeted treatment.