Gastrointestinal mesenchymal tumors are a group of tumors that originate independently from the mesenchymal stem cells of the gastrointestinal tract, with non-directional differentiation and cells rich in CD117 expression, and are the most common mesenchymal tumors of the gastrointestinal tract, with approximately 60% occurring in the stomach. Gastric mesenchymal tumors are found in the gastric body, gastric sinus and fundus cardia in that order. The clinical symptoms of gastric mesenchymal tumor vary depending on the size, location and growth pattern of the tumor, and commonly include upper abdominal discomfort, pain, gastrointestinal bleeding and abdominal masses. The final diagnosis of gastric mesenchymal tumor depends on the postoperative pathological diagnosis, especially immunohistochemistry is very important for the diagnosis. The preoperative clinical diagnostic methods include abdominal CT, abdominal MRI, gastrointestinal imaging, gastroscopy and ultrasound endoscopy, etc. Among them, ultrasound endoscopy is the most significant for preoperative diagnosis of gastric mesenchymal tumor because it can clearly show the structure of gastric wall and the origin level, size and boundary of the tumor, and the common sonogram is a hypoechoic lesion within the intrinsic muscle layer of gastric wall, oval in shape and protruding into the lumen. Therefore, the current clinical diagnosis of gastric mesenchymal tumor before surgery mainly relies on ultrasound endoscopy. However, ultrasound endoscopy does not provide a pathological basis for the lesion and has a certain rate of misdiagnosis, with an overall pathological diagnosis compliance rate of about 75%. In cases where the pathologic diagnosis is not met, the lesions are mainly located in the gastric body and sinus region, but this pathologic non-compliance usually does not affect treatment decisions. Gastric mesenchymal tumors are insensitive to chemotherapy and radiotherapy, and surgical resection is the only effective means of treatment. Because gastric mesenchymal tumors rarely metastasize to lymph nodes, radical surgery with lymph node dissection is not required. The surgical approach is simple, especially for relatively small diameter tumors, and treatment can be achieved by ensuring local excision with negative margins. Because of the above characteristics of gastric mesenchymal tumor, laparoscopic technique is of high value for the surgical treatment of gastric mesenchymal tumor. Laparoscopic resection of gastric mesenchymal tumor is less invasive, faster recovery, and more effective, and has now become the preferred treatment modality for this disease.