Ultrasound medicine after just over 50 years of development, with the continuous innovation of equipment research and development technology, ultrasound diagnostic technology has gone through one step after another, the level of clinical diagnosis continues to improve; with the application of high-grade color ultrasound, has been able to meet the needs of daily clinical diagnosis and treatment work. With the introduction of the third generation of ultrasound contrast agents, ultrasound diagnosis provides a new vision. Conventional ultrasound can find lesions, but for some atypical lesions, it can’t make qualitative diagnosis. With the introduction of ultrasound contrast agent, through intravenous injection of a small amount of contrast agent, it can detect the microcirculation blood supply situation in the lesion, so as to further determine the benign and malignant lesions of the lesion. Currently, the scope of clinical application: 1, qualitative diagnosis of occupying lesions in organs such as liver, gallbladder, pancreas, spleen, kidney, bladder, prostate, uterine adnexa, etc. 2, evaluation of therapeutic effect of tumor (surgery, ablation therapy, chemotherapy) 3, qualitative and localized diagnosis of stenosis of blood vessels and thrombosis Among them, qualitative diagnosis of occupying lesions in the liver is of great significance, and it is possible to clearly define the following through ultrasonography: hepatic hemangioma, liver abscess, hepatic abscess, hepatic tumor, hepatic abscess, hepatic tumor, liver abscess, hepatic tumor, liver abscess, liver abscess, liver abscess and liver abscess. The qualitative diagnosis of localized lesions in the liver is of great significance, through ultrasonography, it can define: liver hemangioma, liver abscess, focal nodular hyperplasia in the liver, liver cancer and other diseases. Methods: Intravenous injection of 1-5 ml of ultrasound contrast medium, name of contrast medium: sulfur hexafluoride microbubbles, which has the characteristics of non-radiation, non-hepatorenal toxicity.