Excess fat in the lumbosacral spinal canal, medically known as intradural epidural lipomatosis, is a rare disease, mostly associated with long-term intake of exogenous steroid hormones and primary Cushing’s syndrome, but can also occur in patients with simple obesity, and is more prevalent in males. It can also occur in patients with simple obesity and is more common in males. If it occurs in patients without a history of glucocorticoid use and without Cushing’s syndrome, it is called idiopathic intradural lipoatrophy. The proliferation of fat tissue compression of the spinal cord and nerve roots can cause patients with low back pain and lower limb numbness and other symptoms. 1. Conservative treatment: It is suitable for patients without clinical symptoms or with mild symptoms, including reducing excessive steroid hormones, reducing weight, etc.; actively treating the primary disease, such as Cushing syndrome, etc., and using anti-inflammatory and analgesic drugs, such as non-steroidal anti-inflammatory drugs, such as ibuprofen, etc., to relieve the symptoms. 2. Surgery: If there is progressive neurological damage and conservative treatment is ineffective, surgical treatment can be chosen, such as decompression of the laminae and lipectomy combined surgery, etc. It is recommended to consult the doctor in time. It is recommended to go to the hospital in time and choose the appropriate treatment plan under the doctor’s guidance to avoid delaying the condition. The above drugs should be used under the guidance of a doctor, avoid self-medication.