Blisters on the buttocks that are painful and itchy may be related to shingles, eczema, contact dermatitis and other causes. 1. Herpes zoster: when a person is infected with chickenpox-herpes zoster virus, blisters may appear on the infected area of the buttocks skin, which may be accompanied by pain, itching and other symptoms. 2. Eczema: Acute eczema with infection can appear on the basis of skin erythema papules, and in severe cases, small blisters can appear, which can be accompanied by pain and itching symptoms. 3. Contact dermatitis: if the buttocks contact with chemical fiber underwear and other allergenic substances, can cause abnormal immune response, can appear pimples, papules, can be accompanied by pain, itching. It is recommended that people with blisters on the buttocks and pain and itching go to the hospital in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.