Blocker resistance is indicated by the detection of a relatively high viral load. Resistance to the blocking agent means that the newly replicated virus has mutated and become resistant to the drug, resulting in the inability of the blocking agent to inhibit the virus. Failure of blockade is often due to a variety of factors that cause the virus in the body can no longer be inhibited by the drug to inhibit replication, the specific manifestation is able to detect the viral load is relatively high. In clinical practice, treatment failure is generally categorized into clinical failure, immunological failure, and virological failure. When resistance to a blocking agent occurs, it means that the virus can no longer be replicated, and other medications need to be taken by a specialist to prevent the virus from continuing to replicate. In addition, in order to avoid the possibility of blocker resistance, patients need to be actively tested under the guidance of a specialist.