Whether connective tissue disease is serious or not should need to be judged according to the patient’s specific condition, not generalized. Connective tissue disease refers to a large group of autoimmune diseases, such as dry syndrome, dermatomyositis, systemic lupus erythematosus and so on. Therefore, determining whether a connective tissue disease is serious or not needs to be based on the actual situation and cannot be generalized. Generally speaking, connective tissue disease is not serious and will not cause much impact on health if it can be diagnosed early and treated in time to control the condition. However, if the disease is not treated in a timely manner and continues to develop, causing lesions in several other organs and systems, it is relatively more serious. When the connective tissue disease is detected, patients should actively cooperate with doctors to carry out standardized treatment, strengthen daily life management, adjust the mentality, and go to the rheumatology and immunology department of regular hospitals for regular follow-up.