Depending on the severity of the disease, plantar fibroma can be treated by surgical excision, chemotherapy, radiation therapy, targeted therapy and so on. 1. Surgical excision: the first choice of treatment for plantar fibroma is surgical excision, usually the patient’s lesion is excised, and the patient’s condition will be controlled and the symptoms will be relieved. 2. Chemotherapy: If the symptoms of plantar fibroma are mild, local infusion chemotherapy can be carried out, which can also inhibit the growth of plantar fibroma, but the process of chemotherapy may cause bone marrow suppression, gastrointestinal symptoms and other adverse reactions. 3. Radiation therapy: because plantar fibroma is easy to recur, so radiation therapy is usually given to patients after surgery to inhibit the recurrence of plantar fibroma, but children and pregnant women are not suitable for radiation therapy. 4. Targeted therapy: patients with plantar fibroma can also undergo targeted therapy, such as using imatinib and other drugs to inhibit tyrosine kinase activity through multi-targets, which can control the progression of plantar fibroma. The discovery of plantar fibroblastoma should be timely and standardized treatment, the doctor assessed to choose the appropriate treatment, and plantar fibroblastoma is prone to recurrence, but also should do regular review. The use of medication should be in accordance with the doctor’s prescription.