There are many clinical causes of chest pain, and attention should be paid to the appropriate differential diagnosis. If middle-aged or elderly patients have chest pain, they must be highly alert to whether it comes from heart-related diseases, such as angina pectoris, myocardial ischemia and acute myocardial infarction, and they can have an electrocardiogram done at the time of pain, which often reflects myocardial ischemia, and if necessary, a coronary angiography to clarify the degree of coronary artery stenosis. In addition, adolescents who present with chest pain accompanied by fever, cough and sputum should pay attention to exclude the presence of pneumonia or specific infections, such as tuberculosis and tuberculous pleurisy, which can be clarified by tuberculin test, sputum examination and chest CT examination. Another part of patients commonly have skin lesions on the chest, such as the common herpes zoster, which can also cause severe pain, usually accompanied by typical skin changes.