Solitary myeloma cannot be cured by itself and needs standardized treatment. Solitary myeloma, also called isolated plasma cell tumor, is a kind of malignant hematopoietic tumor belonging to the plasma cell system, mostly occurring outside the bone marrow, and it is a kind of disease that can’t be cured by itself, and it needs to be timely and targeted treatment once it is detected, or else systemic metastasis and spreading will occur, which will endanger the patient’s life. Generally speaking, early-stage solitary myeloma can be removed through surgical resection or local radiation therapy, and clinical recovery can be realized. In the case of middle and late stage of solitary myeloma, comprehensive treatment is mainly carried out through radiotherapy, chemotherapy and targeted therapy to stabilize the condition and prolong the patient’s survival cycle, but it is more difficult to achieve complete recovery. As single myeloma also belongs to cancer, it is important to follow the doctor’s instruction to standardize the treatment and strive for a better therapeutic effect.