Pain in the middle of the foot, the common clinical causes are mainly the following: a. Septic infection in the interstitial space of the foot, mostly due to the acute inflammatory reaction caused by the skin of the foot breaking down, the patient did not disinfect as soon as possible, and the bacteria on the surface of the skin entered the bottom of the foot along the break. Patients may experience significant swelling, increased skin temperature, and pain in the foot. In this case, surgical incision of the pedal space should be performed as soon as possible to drain out the fluid and pus in the space. Intensive intravenous anti-infection treatment, the symptoms of pain in the middle of the foot can be relieved more quickly. Second, gout, the body purine metabolism abnormal patients who eat more seafood, animal offal and other foods, will cause the body uric acid indicators significantly increased, a large number of uric acid accumulation in the foot joints and other places, can cause pain symptoms in the middle of the foot obvious. In this case, patients can take colchicine and sodium bicarbonate orally, and apply Xuanming powder externally to the feet to improve the symptoms of pain in the middle of the feet.