A positive IgG antibody to Mycoplasma pneumoniae refers to a previous infection with mycoplasma and does not require specific treatment at this time. For Mycoplasma pneumoniae antibodies, there are two types: lgM and IgG. IgM refers to the marker of recent infection, while IgG refers to the marker of previous infection. If the patient is IgM positive and has associated clinical symptoms, anti-infective treatment is required. The preferred drugs are macrolides such as erythromycin and azithromycin, etc. Quinolones such as levofloxacin and moxifloxacin can also be used. No special treatment is needed if IgG is positive. If the patient has a long duration of illness and the titer of IgG antibody is progressively increasing, it needs to be considered as a possible recent infection and anti-infection treatment should be administered.