Gastroesophageal reflux is not the same as reflux esophagitis. Reflux esophagitis is a clinical manifestation of GERD. Reflux esophagitis, the main clinical manifestation of GERD, is the result of long-term irritation of the esophagus by refluxing stomach acid. Gastroesophageal reflux disease (GERD) is the reflux of gastric juices into the esophagus in an amount greater than the normal limit, with or without symptoms of esophageal mucosal damage (e.g., esophagitis). Medication is the first line of treatment for GERD. Pharmacologic treatment of GERD often requires the management of other co-morbidities, such as functional gastrointestinal disorders, chronic gastritis, bile reflux, visceral hypersensitivity, and intestinal dysbiosis. Commonly used medications include acid-suppressing agents, pro-gastrointestinal stimulants, mucosal protectants, and bile-binding agents. Acid suppressants include omeprazole, lansoprazole, ranitidine, famotidine, etc., which can inhibit the secretion of gastric acid and reduce the damage of reflux to the esophagus. Gastrointestinal stimulants commonly include domperidone. Mucosal protective agents are various bismuth agents such as bismuth potassium citrate. Bile-binding agents are calamine and others. Medications should be used under medical supervision.