Palmar-plantar pustulosis, a recurrent pustular rash of the palmoplantar region, is characterized by recurrent episodes of sterile pustules with negative bacterial cultures. Considered by some to be a form of psoriasis, it is now considered to be a separate disease. It is characterized by a high prevalence in women, especially in those who smoke, so smoking cessation is a prerequisite for treatment. Other common causes may be related to Helicobacter pylori infection, and there is a close relationship with thyroid disease. Patients with diabetes are also risk factors. There are various methods of treatment: 1. For patients with mild symptoms, topical medications such as a strong corticosteroid, halometasone ointment, twice a day during the day and topical tazarotene at night can be used. 2, oral medication, the first choice of Avia capsules, the efficacy of this drug is more accurate, but affects fertility, the desire to have children within two years can not be used. Next is the tetracycline class of drugs, such as minocycline hydrochloride, doxycycline, etc., for patients with mild disease has a certain degree of efficacy, severe patients are not as good as the effect of Avi A capsules. Other cyclosporine and aminoglutethimide are also available, but the side effects are large, and the liver and kidney function abnormalities are carefully selected. 3, physical therapy, the first choice of superficial X-ray irradiation, we are currently treating cases can relieve symptoms in the short term. This treatment method, is more troublesome, once a week irradiation, generally need about four times of treatment, will be clinically cured. Ultraviolet irradiation, also optional, is available every other day, and most require at least twenty treatments to be effective. Regardless of the type of treatment option, quitting smoking is the key to successful treatment, and it is also important to look for factors that contribute to the onset of the disease and to rule out other diseases.