A sudden feeling of emptiness in the heart is clinically more common in anxiety disorders or depression. When patients feel empty in their hearts, accompanied by anxiety, worry, fear or fidgeting and irritability, patients often appear to be on tenterhooks and on edge, so they experience an empty heart and a feeling of uncertainty and pain. Once anxiety disorder is diagnosed, good treatment results can be achieved clinically through anti-anxiety medication or psychotherapy. For example, the application of benzodiazepine anxiolytics has a fast onset of action and good therapeutic effect, and should be applied in short term and small doses. When patients appear to be empty in the heart, and accompanied by depressed mood, slow thinking, low self-evaluation, often patients with depression, once diagnosed with depression, the need for antidepressants system specification, especially the application of 5-hydroxytryptamine reuptake inhibitors, can achieve good therapeutic results, such as the application of paroxetine, sertraline, fluoxetine and other drugs.