Both rabeprazole and omeprazole belong to proton pump inhibitors, which are acid-suppressing drugs, and the difference between the two lies in the early and late development and marketing time. Omeprazole belongs to the first generation of proton pump inhibitors, while rabeprazole should be the fourth generation of proton pump inhibitors. The difference in efficacy between the two also varies from person to person, and it is possible that most people can get significant relief of clinical symptoms by taking omeprazole, whereas a small number of people may have unsatisfactory results with omeprazole and need to be replaced with rabeprazole. In addition, there may also be differences in specifications and dosage between the two, which are related to the manufacturer. Therefore, rabeprazole and omeprazole are actually the same class of drugs, if the patient exists in the stomach upset, need to take a proton pump inhibitor can be preferred to omeprazole treatment. Of course, provided that there is no contraindication to omeprazole, such as allergies or cardiac disease patients are recommended to switch to other proton pump inhibitors, not to take omeprazole, specific need to consult a specialist.