Patients in deep coma are usually unlikely to have limb or body movement, consciousness, eye movement and reflexes to light or corneal reflexes, etc. Most of them are caused by severe intracranial lesions, which can also occur in patients who have undergone mainly massive cerebral infarction, massive cerebral hemorrhage, severe craniocerebral trauma and severe encephalitis, and in patients with severe hypertension. If the patient has diabetes mellitus, it can also be caused by high blood sugar or severe hypoglycemia. Patients generally may cause increased intracranial pressure at the same time, and if severe intracranial pressure increases may cause brain herniation, which can cause patients to die. The main is to actively treat the primary disease, but also can be carried out to wake up the brain treatment, commonly used drugs are wake up the brain Jing and compound musk, lowering the cranial pressure treatment commonly used drugs are mannitol and glycerol fructose and so on.