Heartburn and stomach acid at night can be considered to be related to reflux esophagitis, peptic ulcer or stomach cancer. 1. Gastroesophageal reflux disease (GERD): it is a series of uncomfortable symptoms and complications caused by the reflux of gastroduodenal contents into the esophagus, among which reflux and heartburn are the most common and typical symptoms, and when the reflux stimulates the esophagus, it can cause chest pain. 2. Chronic gastritis: chronic inflammatory lesions of the gastric mucosa, of which Helicobacter pylori infection is the most common cause, can be manifested as discomfort in the middle and upper abdomen, burning pain, dull pain, but also acid reflux, belching (hiccups) and other symptoms. 3. Peptic ulcer: when the gastrointestinal mucosa has an inflammatory defect, it can cause a series of symptoms, such as burning pain in the epigastric abdomen, acid reflux, belching (hiccups) in some cases, in the night vagus nerve excitation, gastric acid, more likely to have acid reflux performance. It is recommended that patients with nighttime acid reflux, heartburn symptoms, timely medical care, complete gastroscopy and other related examinations, to determine the cause of the disease, and then the cause of the symptomatic treatment.