Long-term use of B vitamins does not usually result in an increase in blood creatinine. Long-term use of B vitamins is not recommended for patients without specific medical advice and may lead to damage such as peripheral neuritis. B vitamins include vitamin B1, vitamin B2, vitamin B6, and niacinamide. Clinical supplementation of B vitamins is commonly used with B complex vitamin tablets. Vitamin B complex is mostly used in the treatment of diseases such as beriberi and pellagra, and needs to be administered under the supervision of a clinician. If not special medical advice, patients are not recommended to take B vitamins for a long time, long-term use of the drug usually does not lead to creatinine increase, but may appear peripheral neuritis, sensory abnormalities, abnormal numbness of the limbs and other manifestations. After taking the drug, if there is irritability, fatigue, skin flushing, itching and other adverse reactions, you need to stop using the drug in time. Allergic to the drug is prohibited, pregnant and lactating women should be used with caution under the guidance of clinicians. If the patient needs to apply B vitamins, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse effects.