Statin lipid regulators can be used in combination with beta lipid regulators. Statin lipid regulators lower total cholesterol and LDL cholesterol by inhibiting the synthesis of cholesterol through the inhibition of key enzymes for cholesterol synthesis in the body. By inhibiting the synthesis of very low-density lipoprotein and triglycerides in the body and promoting the breakdown of both, beta-lipid regulators lower triglycerides in the body. The two have different mechanisms of action and can be used in combination. For mixed hyperlipidemia, one lipid-regulating drug alone sometimes cannot completely correct it. The combination of fibrates and statins can effectively improve the abnormalities of lipids due to the complementary mechanism of action. Moreover, some studies have proven that the combination of the two is safe and effective. However, when using them, we should pay attention to the choice of fenofibrate, which is safe and effective, and the dosage of statins should not be too high. At the same time, we should pay attention to take them separately, for example, take fibrates in the morning and statins in the evening. It is important to regularly monitor the body’s improvement of blood lipids, liver and kidney function, and kinase. Patients should also pay attention to muscle weakness and pain during use, and communicate with their doctors regularly to ensure the efficacy and safety of the statin and fibrate combination.