The causes of heartburn pain are mainly categorized into physiological and pathological factors. 1. Physiological factors: can be seen in pregnancy, may be due to increased intra-abdominal pressure, resulting in lower esophageal sphincter dysfunction, food reflux. It can also be seen in certain foods or drugs cause gastric mucosal damage, heartburn pain. Or see in the mental tension, can also appear heartburn pain. 2. Pathologic factors: (1) Esophageal diseases: such as esophageal ulcer, sliding diaphragmatic hernia, reflux esophagitis, Barrett’s esophagus and so on. (2) Gastric and duodenal diseases, such as gastritis, peptic ulcer, postoperative cardia, cardia cancer, incomplete pyloric obstruction. (3) Others such as cholecystitis, gallbladder, hepatic and bile duct stones. If heartburn pain occurs, persists without relief or has frequent attacks, or is accompanied by other digestive discomfort symptoms, you need to go to the hospital as soon as possible, and the doctor will formulate an individualized diagnosis and treatment plan according to the specific condition, so as to avoid delaying the condition.