The causes of perianal eczema are complex, and the treatment mainly includes topical drugs and oral drug therapy. Clinically used topical drugs, including glucocorticoid hormones, calcium-regulated phosphatase inhibitors and so on. The cause of perianal eczema has not been fully clarified, and it is considered to be related to the joint action of various internal and external factors. The symptoms of patients are different, the treatment is also different, mainly symptomatic treatment. 1. Topical medication: For subacute and chronic eczema in fixed areas, glucocorticoid topical medication can be given, such as hydrocortisone butyrate cream and mometasone furoate cream. Calcium-modulated phosphatase inhibitors, such as tacrolimus ointment, pimecrolimus cream, with coal tar cream and other medications, the effect is better. 2. Oral drug treatment: Perianal eczema can cause obvious itching sensation, and antihistamine drugs, such as loratadine and cetirizine, can be given when necessary to improve the patient’s quality of life. If secondary bacterial infection, antibiotic drugs can be given, such as cefadroxil, amoxicillin, erythromycin and so on. When obvious discomfort occurs in the perianal area, such as itching, redness, swelling, oozing, erosion or long-term recurrent episodes, it is recommended to go to the dermatology department of the hospital, and appropriate medication is given under the guidance of the doctor, which can help to alleviate the symptoms.