The main symptoms of drug rash are rash, itching, and oral mucosal erosions, which can cause pain and peeling of the oral mucosa. In the case of more severe drug rashes, they are often accompanied by oral and mucosal erosions, which is an important indicator to distinguish general drug rashes from severe drug rashes. The details are as follows: 1. Milder and more common is a fixed drug rash, with a purplish-red rash in localized areas, which reappears after the next medication; 2. After using penicillin or amoxicillin, there is a star-shaped rash, disseminated pinpoint red papules all over the body, with more pronounced itching; 3. A rash of erythema multiforme all over the body, which is also seen as a congested type of erythema all over the body. For the treatment of drug rash, early discontinuation of allergy-causing drugs is the key to treatment, and patients should use anti-allergy drugs appropriately; moderate to severe drug rash should be treated with medium doses of hormones and early full doses; in addition, complications should be prevented.