The most common causes of sudden pain and weakness in the bones of the hands and feet are over-exercise, rheumatoid arthritis, osteoporosis, Parkinson’s disease and so on. 1. Excessive exercise: If the patient is engaged in strenuous sports or high intensity work, it is easy to cause lactic acid accumulation, causing the whole body bone soreness and weakness and accompanied by pain, usually after resting the symptoms can be relieved. 2. Rheumatoid arthritis: when rheumatoid arthritis is in acute attack, it is easy to have pain in many joints of the whole body, which may be accompanied by weakness of limbs, and joint deformity and difficulty in movement may also occur in patients with serious symptoms. 3. Osteoporosis: Osteoporosis can cause sudden pain and lack of strength in the bones of the hands and feet, which is common in the middle-aged and old people, especially in post-menopausal women, and may be accompanied by compression fractures. 4. Parkinson’s: If you are a Parkinson’s patient, you may experience resting tremor, uncontrolled pain and shaking of the hands and feet, and the patient is usually accompanied by slow movement and abnormal gait. Caused by sudden pain inside the bones of the hands and feet without strength more reasons, may also be related to gouty arthritis, cerebral blood supply insufficiency and other reasons, if the symptoms persist, it is recommended to promptly go to the hospital to identify the cause of the disease, targeted treatment.