In the clinic for epidemic cerebrospinal meningitis, the first choice of drugs is ceftriaxone or vancomycin, but for epidemic cerebrospinal meningitis, not all of them are this mode of treatment, more is the first choice of drug treatment, as soon as possible to carry out laboratory tests, clear cerebrospinal fluid inside the relevant bacterial blood cultures, according to bacterial drug sensitivity of the results of the choice of the more sensitive drugs can be an effective treatment of epidemic cerebrospinal meningitis. Epidemic cerebrospinal meningitis can be effectively treated by choosing more sensitive drugs according to the results of bacterial drug sensitization, which can reduce the emergence of bacterial drug resistance. It is very important to choose sensitive antibiotics to treat epidemic cerebrospinal meningitis, otherwise the antibiotics applied will not be able to kill the bacteria completely, causing more serious forms of damage and delaying the patient’s treatment, which is a more important point. And not only the application of antibiotics, like rehydration, improve circulation, prevent convulsions and other related drugs should be applied, so it is a comprehensive treatment process.