Transcranial magnetic stimulation therapy can treat depression, but its effectiveness varies from person to person and is usually used when other treatment modalities are not effective. People with depression also need medication and psychotherapy. Symptoms in depressed patients are characterized by low mood, loss of interest, and reduced activity. Repetitive transcranial magnetic stimulation therapy is painless and non-invasive. The treatment can affect deep brain tissues, such as the hippocampus, thalamus and other cerebral cortical excitability and blood flow activity, and works by changing neurotransmitters and cytokines in the brain, which can be used to treat refractory depression. However, repeated transcranial magnetic stimulation therapy has the potential to induce epilepsy, mania, and headaches and other adverse reactions, and should be used after evaluation by experts. Depression can also be treated with medication, such as the antidepressant drug Doxepin, as prescribed by the doctor. Patients also need cognitive behavioral therapy, psychotherapy and other comprehensive treatment.