The generic name of citalopram oxalate is escitalopram oxalate, sertraline and escitalopram oxalate are both antidepressant drugs, but there are some differences in their composition, efficacy and indications, so it is not possible to compare which one works better. Sertraline is used to treat depression with anxiety, depression with or without a history of mania, and can effectively prevent recurrence of depression after satisfactory efficacy. It is also used to treat obsessive-compulsive disorder. Symptoms of malaise such as dry mouth, excessive sweating, indigestion, dizziness and tremor may occur after taking the drug. Sertraline is prohibited in combination with monoamine oxidase inhibitors and is contraindicated in people who are allergic to sertraline. Escitalopram oxalate is used for various types of depression. Some patients may experience adverse reactions after taking it, such as decreased appetite, nervousness and restlessness, sleep abnormalities and attention disorders. Taking Escitalopram Oxalate is prohibited in combination with Pimozide and Linezolid. When taking sertraline and escitalopram oxalate, patients are recommended to use it under the guidance of a physician to avoid aggravating the condition.