Lip spots need to be treated according to the cause of the disease, and common causes include melanosis, pigmented nevi, and so on. Generally, medication, physical therapy and surgery are used. 1. Melanosis: Long-term sun exposure, endocrine disorders, long-term application of hormone drugs, excessive use of cosmetics, etc. can easily cause melanosis, thus forming spots on the lips, which can be treated with topical hydroquinone cream under the guidance of a doctor, and can also be treated with physical therapy, such as photon rejuvenation, which can break up the melanin and expel it from the body, thus achieving the effect of lightening lip spots. 2. Pigmented nevus: pigmented nevus is a benign proliferation of melanocytes, which is common in the head and face, manifesting itself as pimples, patches or plaques on the surface of the skin, with the color of brown, tan, black, etc. Smaller pigmented nevus can be treated by the use of light rejuvenation methods. Smaller pigmented nevi can be removed by laser treatment, such as CO2 laser, and if the symptoms are serious or have a tendency of malignant transformation, surgical excision can be used for treatment. Lip spots may also have other causes, it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease and then give targeted treatment.