There is no fastest solution for costal neuralgia, the more effective solutions include physical therapy and medication such as massage and hot compresses, oral pain medication, etc., which can effectively relieve pain. 1. Physical therapy: for costal neuralgia, localized hot compresses, massage or acupuncture can effectively relax the nerves and muscles, thus relieving the pain or muscle spasm caused by acute attacks and other symptoms, and can help to improve the nerve inflammation or muscle damage. However, the relief effect of physical therapy during an acute attack is small, so it is generally recommended to choose physical therapy during a chronic attack. 2. Medication: For intercostal neuralgia secondary to Mycobacterium tuberculosis, herpes zoster and other pathogenic infections, antiviral drugs such as oseltamivir, acyclovir or interferon can be used. For primary intercostal neuralgia caused by bone, muscle or nerve injury, you can take ibuprofen, diclofenac sodium and other analgesic drugs for sedation and pain relief. After an episode of intercostal neuralgia, it is recommended to go to the hospital for blood tests and imaging tests to help determine the location and cause of the pain, so as to treat it in time.