① Reduce the accumulation of uremic toxins and metabolic wastes and increase the excretion of uremic toxins using extrarenal routes; ② Avoid or eliminate risk factors for the rapid deterioration of CRF; ③ Treat the original disease of CRF and control the various causes of progressive development of CRF; ④ Treat the symptoms and complications for each system. Extra-renal detoxification pathways: – Intestinal dialysis: choose different colonic dialysis fluid machines or high retention enemas according to the patient’s gender, age, physique and condition – Skin dialysis: open the ghost door, cleanse the house” – make water evil excreted from the skin; detoxify the surface and the interior, and dredge the upper source to facilitate the lower flow. Choose herbal fumigation therapy, herbal medicine bath therapy, herbal meridian foot bath therapy .