Cholangiocarcinoma refers to malignant tumor of extrahepatic bile duct originating from the confluence of left and right hepatic ducts to the lower end of common bile duct. Surgical resection is the best treatment for early bile duct cancer and the only treatment that can achieve clinical cure, but the surgery is difficult and technically demanding. Our department applies ultrasound, CT, MRCP, PTC, ERCP and other imaging technologies to accurately locate the pathological location of bile duct cancer, and selects the following different surgical methods according to the location of bile duct cancer, invasion scope and general conditions of patients, with good results. Upper segment cholangiocarcinoma, also known as hilar cholangiocarcinoma, is the most difficult tumor among cholangiocarcinoma to operate. Radical surgery for hilar cholangiocarcinoma is collectively called radical surgery for hilar cholangiocarcinoma, but there are five types of hilar cholangiocarcinoma, and each type has different surgical treatment methods, whether to cut the liver or not and the scope of cutting the liver are different. Our department has accumulated rich clinical experience in the surgical treatment of complex unresectable hilar cholangiocarcinoma, and we have successfully operated many times to save difficult cases referred to our department from overseas. For middle-stage cholangiocarcinoma, we perform cholangiocarcinoma resection with hepatic artery-portal vein stemming (pulsation), and pancreaticoduodenectomy for infiltrating lower bile duct; for lower-stage cholangiocarcinoma and pot-belly cancer, pancreaticoduodenectomy is generally performed, but for early pot-belly cancer in elderly patients with serious cardiopulmonary disease, local pot-belly cancer resection is feasible. For cholangiocarcinoma that cannot be radically resected, palliative bile-intestinal drainage, percutaneous hepatic percutaneous bile-intestinal drainage or PTCD are performed according to different conditions.