Hypersensitivity reactions of the gallbladder, i.e. gallbladder motility disorders, are caused by: disturbances in the neural network within the gallbladder wall; hypersensitivity reactions of the gallbladder; and early stages of gallbladder inflammation. Biliary tract dyskinesissyndrome includes biliary tract dysmotility (dyskinesis, abnormal biliary emptying rate), biliary tract dystonia (abnormal biliary muscle tone) and biliary tract ataxia (impaired coordination between biliary tract components). The clinical manifestations of this disease, which is mostly seen in women, are very similar to those of gallbladder stones and mainly present as abdominal pain, which is paroxysmal colic in the upper abdomen or right upper abdomen. Prevention and treatment of hypersensitivity reaction of gallbladder caused by cholangiocarcinoma: 1. Maintain a happy psychological state, develop good dietary habits, abstain from spicy food, eat less thick and greasy food, and do not drink strong alcohol. 2.For people over 40 years old, especially women, they should have regular ultrasound examination, and if gallbladder inflammation, gallstones or polyps are found, they should follow up the examination, and if any change in the condition is found, early treatment should be carried out. 3.Before actively treating cancerous lesions, remove the causative factors that may cause cancerous lesions sooner or later. The prognosis of cholangiocarcinoma is not very good, among which the prognosis of cholangiocarcinoma is extremely poor. The average survival of cholangiocarcinoma surgical resection group is 13 months, and rarely survives for 5 years. Preoperative preparation: Due to the wide range of resection for cholangiocarcinoma of the hilar region, in many cases, simultaneous lobectomy is required, and patients often have severe jaundice, malnutrition and immune deficiency, and patients with cholangiocarcinoma are generally older, so good preoperative preparation is very important. General preparation: systematic laboratory and imaging examinations, understanding the systemic condition, replenishment of physiologically required water and electrolytes, etc., and preoperative and intraoperative use of antibacterial drugs. Preoperative cardiopulmonary function must be confirmed to be able to tolerate surgery, and mild cardiopulmonary dysfunction should be corrected preoperatively. Coagulation disorders should also be corrected preoperatively as much as possible.