1.What are the current treatments for bile duct cancer? The traditional treatment methods of bile duct cancer include surgery, radiotherapy and chemotherapy, and the new treatment methods include photodynamic therapy and intracavitary radiofrequency ablation. 2.What is radiofrequency ablation? Radiofrequency is the electromagnetic wave of certain specific frequency, the frequency of medical radiofrequency is 460-500 KHz, and the medical radiofrequency electromagnetic wave can activate the polar molecules inside the tissue to generate electromagnetic oscillation and heat, and the temperature can reach more than 100 degrees in a short time to inactivate the tumor. This means of local physical high temperature inactivation of tumor is called radiofrequency ablation. Intracavitary radiofrequency ablation of isolated pig liver experiment: the ablation catheter electrode generates heat to form distinct necrotic foci in the pig liver. 3.What is intracavitary radiofrequency ablation? The traditional RF ablation electrode needle is rigid and unbendable, which is commonly used for ablation of parenchymal organ tumors, such as liver tumors. The new intracavitary radiofrequency ablation nests the two electrodes emitting radiofrequency energy in a soft catheter with a diameter of only 2-3mm. 4.What is the difference between radiofrequency ablation and traditional open surgery, chemotherapy and radiotherapy? Radiofrequency ablation is a physical minimally invasive treatment, which inactivates tumor locally through specific high temperature, so that patients do not need to undergo surgery, and the damage is smaller than that of open surgery, and recovery after surgery is fast. It also does not have the toxic side effects caused by chemotherapy, such as hair loss, vomiting, bone marrow transplantation, etc. It is non-radioactive and does not have the risk of causing radioactive hepatitis. 5.Why should advanced cholangiocarcinoma receive intracavitary radiofrequency ablation treatment? Cholangiocarcinoma is insidious and often advanced when it develops, so radical surgery cannot be performed. At present, most advanced cancers can only receive ERCP (transendoscopic cholangiopancreatography) or PTCD (percutaneous hepatic percutaneous cholangiography drainage) to place stents, which can relieve patients from obstructive jaundice to a certain extent, but the continuous growth of tumor cannot be effectively controlled. The placed stents are easily blocked due to the continued survival of the tumor leading to treatment failure. Therefore, how to take effective means to control the continued growth of tumor after the placement of biliary stents is a hot topic of current research. Intraluminal radiofrequency ablation can effectively control tumor growth locally, delay biliary obstruction, improve patient’s survival quality and prolong survival period. 6.What is the process of intracavitary radiofrequency ablation? The most critical step of intracavitary radiofrequency ablation is to accurately place the energy-emitting radiofrequency catheter into the bile duct cancer, which can be performed through 2 ways, one is percutaneous local percutaneous cholangiography route (PTCD) and the other is transendoscopic retrograde cholangiography (ERCP). Both are minimally invasive means, with little patient injury and fast postoperative recovery. 7.What are the side effects of intracavitary radiofrequency ablation? Intraluminal radiofrequency ablation is a local physical ablation, which is safe and reliable and does not have toxic side effects of radiotherapy. 8.Is there any radioactivity in intracavitary radiofrequency ablation? Intracavitary radiofrequency ablation is not radioactive. 9.What are the indications for intracavitary radiofrequency ablation? At present, the main indications for intracavitary radiofrequency ablation are: advanced bile duct cancer, early bile duct cancer that patients cannot tolerate surgery or are unwilling to undergo open surgery, and bile duct obstruction re-emerging in patients with bile duct cancer who have received stent placement. 10.Do I need chemotherapy after receiving intracavitary radiofrequency ablation? Patients receiving intracavitary radiofrequency ablation do not affect the comprehensive treatment of patients, and intracavitary radiofrequency ablation can inactivate most of the cancer and reduce the tumor load, which is more conducive to chemotherapy. 11.What is the cost of intracavitary radiofrequency ablation and can it be reimbursed? Intracavitary radiofrequency ablation is a medical insurance treatment item and can be reimbursed according to the relevant medical insurance policies.