Walking for a long time hand swelling may be caused by gravity, nephrotic syndrome, right heart failure and other factors. 1. Gravity: in the process of walking, the arm is in a prolonged period of time in the sagging state, under the influence of gravity, may make the blood in the hand is not easy to return, a large amount of blood stagnation in the hand, there may be a long time walking hand swelling. 2. Nephrotic syndrome: protein in the human body has the role of maintaining the osmotic pressure, which can prevent the liquid in the blood vessels from leaking out of the tissue fluid. When there is nephrotic syndrome, may be due to walk longer, resulting in a large number of proteins from the urine discharged, so that the plasma colloid osmotic pressure is reduced, the water may leak into the tissue fluid, and then appear walking time long hand swelling. 3. right heart failure: right heart failure when walking for a long time, may lead to blood stagnation in the periphery is difficult to reflux, thus walking for a long time the situation of hand swelling. When walking for a long time hand swelling, should promptly consult a doctor, under the guidance of the doctor to improve the relevant examination, to clarify the cause of the disease, and active treatment.