Lymphoma targeted drugs commonly include CD20 monoclonal antibody, CD30 monoclonal antibody, small molecule targeted drugs and so on. Lymphoma is a malignant disease of blood system with unknown etiology, which may be related to immunity, heredity and other factors, and mainly manifests as painless lymph node enlargement. Clinical radiotherapy, chemotherapy and targeted therapy are mainly adopted to improve patients’ symptoms and prolong the survival period, and common targeted drugs include CD20 monoclonal antibody (rituximab), CD30 monoclonal antibody (vibritumomab), and small-molecule targeted drugs (ibrutinib, zerbutinib, obrutinib). Lymphoma should pay attention to regular review, regular monitoring of symptoms, and timely consultation when discomfort occurs. In daily life, we should pay attention to keep the living place clean and quiet, open the windows for ventilation, have a light diet, avoid spicy and stimulating food, take proper exercise and keep enough sleep.