Differential diagnosis of cerebral palsy – motor developmental backwardness 1. Developmental indicators include simple motor developmental backwardness, language developmental backwardness or cognitive developmental backwardness. Motor developmental delays include gross and fine motor movements. Recent studies suggest that the condition should also include lags in sleep pattern changes. Children should be evaluated when they do not respond to sound or visual stimuli at 6 weeks of age, do not respond socially at 3 months of age, still have poor head control at 6 months of age, do not sit at 9 months of age, do not use their fingers at 12 months of age, do not walk or say single words at 18 months of age, do not run or say words at 2 years of age, and cannot climb stairs or communicate with simple words at 3 years of age. Crawling movements may be missed because the child does not need to perform them, and therefore should not be used as an indicator of developmental milestones. Li Shuidi, Department of Child Neurorehabilitation, Guangdong Maternal and Child Health Hospital 2. Comprehensive developmental backwardness Children under 5 years of age in the early stages of development with multiple developmental milestones of backwardness, who are too young to complete a standardized systematic test of intellectual functioning, and whose severity level of the condition cannot be assessed with certainty, are diagnosed with comprehensive developmental backwardness. However, the assessment should be repeated after a period of time. The incidence is about 3%. Common causes include genetic disorders, embryonic drug or toxic teratogenesis, environmental deprivation, intrauterine malnutrition, intrauterine hypoxia, intrauterine infection, trauma, encephalopathy of prematurity, central nervous system trauma and infection in infancy, and lead poisoning. 3.Developmental coordination disorder ① The acquisition and execution of motor coordination is lower than the motor skills that should be acquired by normal peers, and the movements are clumsy, slow, and imprecise; ② This motor disorder will continuously and significantly affect daily life and schooling, work, and even recreation; ③ The disorder appears early in development; ④ The lack of motor skills cannot be explained by mental retardation or visual impairment; nor is it caused by cerebral palsy, muscular dystrophy, and degenerative diseases caused by motor disorders. 4. autism spectrum disorder ① persistent deficits in social communication and social interaction that exist or have existed in multiple contexts; ② abnormalities in restricted, repetitive behaviors, interests, or activity patterns. Requires manifestation of at least 2 of the following 4, either in the form of presenting symptoms or in the form of a history: stereotyped or repetitive motor movements, use of objects, or speech; persistent sameness, inflexible or ritualized speech or nonverbal patterns of behavior; highly restricted fixed interests that are unusual in terms of intensity and concentration; overreaction or underreaction to sensory input, or perception of the environment in terms of unusual interests in terms of perception of the environment; ③ Symptoms appear early in development, perhaps early on when they are not evident due to limitations in the social environment or are masked by staged learning; ④ Symptoms result in very severe functional deficits in many important areas of society; ⑤ Deficits cannot be explained by intellectual disability or global developmental delay, and sometimes when intellectual disability and autism spectrum disorder are present together, social communication skills are usually below the level of intellectual disability. Some children with autism spectrum disorders may have motor delays that can be mistaken for global developmental delay or early manifestations of cerebral palsy.