Long acne clinically known as acne, is a follicular sebaceous gland unit of chronic inflammatory skin disease, girls with acne can be treated through general treatment, topical medication, oral medication, phototherapy and other treatment solutions. 1. General treatment: Choose water or suitable cleansing products to remove excess oil, dander and bacterial mixtures from the skin surface, pay attention to oil control and moisturizing, and use mild moisturizing milk externally. Avoid squeezing and scratching the skin lesions with hands. Limit the intake of high glycemic index foods and milk that may trigger or aggravate acne, keep bowel movement smooth, and avoid staying up late. 2. Topical medications: Topical medications such as Vitamin A cream, benzoyl peroxide, antibiotics such as fusidic acid cream, erythromycin ointment, etc. can be used for treatment. 3. Oral medication: antibiotics preferred tetracyclines such as minocycline, isotretinoin can inhibit sebaceous secretion of sebaceous glands, regulate the keratinization of follicular sebaceous gland ducts, improve the anaerobic environment of the hair follicles, anti-inflammatory and prevent the formation of keloid scars and other roles, for nodular cystic acne with excessive seborrhoeic overflow. 4. Phototherapy: LED blue light or red light is used to treat mild to moderate lesions; photodynamic therapy (PDT) uses 5-aminolevulinic acid (ALA) externally to enrich the follicular sebaceous gland units, and the addition of red light is suitable for severe acne. If a girl has acne, parents are advised to bring her to the hospital for examination and diagnosis, and to choose the appropriate treatment under the guidance of the doctor. The medication should be used in accordance with the doctor’s instructions, and should not be used on its own.