The main goal of treating hypertension is to control blood pressure up to the standard and minimize the overall risk factors for the occurrence of cardiovascular and cerebrovascular complications and death. In recent years, many scholars at home and abroad have proposed that chronotropics can be used as a comprehensive hypertension treatment strategy to control blood pressure while restoring the normal recent rhythm of blood pressure in hypertensive patients. However, in clinical work, we will find that some hypertensive patients (especially the elderly) have unsatisfactory blood pressure control in the cold winter months. It can be seen that the prevention and control of hypertension in winter is of great importance for guiding the treatment of temporal hypotension. Lifestyle interventions play an important role The non-pharmacological treatment of winter hypertension mainly refers to lifestyle interventions. A large number of studies have confirmed that good lifestyle interventions have a very important role in preventing and controlling blood pressure and reducing cardiovascular events. First of all, hypertensive patients should pay special attention to prevent cold and keep warm in winter and avoid cold stimulation, especially when cold wave comes and the temperature drops suddenly, pay attention to add clothes in time. Secondly, we should strictly control sodium intake, ≤6 g per day, and eat less oily food, more calorie-producing and nutrient-rich food, and more fruits and vegetables that supplement trace elements and vitamins. Again, hypertensive patients without serious cardiovascular disease should adhere to appropriate exercise in winter to improve cold tolerance and control the body mass index (BMI), such as jogging, brisk walking, tai chi, etc. In addition, strict abstinence from smoking and alcohol and maintaining a calm mind are also important for the treatment of hypertension. Drug recommendation ACEI/ARB + β-blocker Reasonable adjustment of antihypertensive drugs is the key to the treatment of hypertension in winter. The principles of winter hypertension antihypertensive drug adjustment mainly include the following: comprehensive adjustment of antihypertensive drugs according to blood pressure levels, target organ damage, other concomitant clinical manifestations and risk factors; emphasis on small doses of combined antihypertensive, when using a single drug or a combination of two drugs as the starting treatment, in order to achieve the standard of blood pressure reduction, if necessary, can be increased to the full dose. When monotherapy is used in winter hypertensive patients, drugs such as ACEI, ARB, CCB and diuretics can be chosen. We recommend treatment with either an angiotensin II-converting enzyme inhibitor (ACEI) or an angiotensin II receptor antagonist (ARB) in combination with a beta-blocker. ACEIs can control blood pressure from the core mechanism of winter hypertension by inhibiting over-activation of the RAS system, while beta-blockers can act by suppressing over-activated sympathetic nerve activity. It is important to note that in the latest 2013 European Society of Cardiology (ESC) guidelines, beta-blockers are no longer used alone as first-line agents to lower blood pressure. In addition, previous studies have shown that cold exposure increases blood pressure by activating L-type calcium channels; therefore, when blood pressure control remains suboptimal with ACEI/ARB combined with beta-blockers in hypertensive patients, a calcium antagonist (CCB) may be added appropriately for triple antihypertensive lowering. We would also like to point out here that the 2013 ESC guidelines emphasize that diuretics as the cornerstone drug for antihypertensive treatment should be paid special attention in the winter antihypertensive strategy, because water consumption is relatively reduced in winter, and if diuretics are used in high doses, a large amount of water is lost from the body, which can easily lead to highly concentrated blood and increased blood viscosity, thus increasing the risk of stroke. In conclusion To conclude, hypertension chronotherapeutics is gaining more and more attention from clinical practitioners as a comprehensive hypertension treatment strategy. In addition to the circadian rhythm and morning peak phenomenon, hypertension also has biological rhythms such as seasonal changes and rapid climate changes. The mechanism of hypertension in winter is a combination of multiple factors. Cold exposure activates the SNS, which in turn increases RAS activity, and a series of biologically active substances change, leading to an increase in blood pressure. In addition, oxidative stress and inflammatory responses are also involved in the development of winter hypertension due to cold exposure. Lifestyle changes such as exercise and diet can also cause an increase in blood pressure in winter. The problem of poor winter blood pressure control in hypertensive patients has become one of the frequently encountered problems in clinical practice. Therefore, it is of great importance to master the winter strategy of hypertension therapeutics for the prevention and treatment of hypertension. For winter hypertension, we need to carry out active and good lifestyle interventions to enable patients to pass the cold winter season smoothly by reasonable adjustment of antihypertensive drugs.