High LDL can be treated with oral lipid-lowering medications and a low-fat diet. LDL is the lipoprotein with the highest cholesterol content and is a major risk factor for atherosclerosis. LDL is considered high when it is ≥ 4.1 mmol/l. Pharmacological treatment can be with statins (atorvastatin, resuvastatin), fibrates (fenofibrate), intestinal cholesterol absorption inhibitors (ezetimibe) and some proprietary Chinese medicines such as Lipotecan and Lipitor. Diet should be adjusted to low-fat diet, consume less animal offal, oil and grease, put less cooking oil in stir-fry, and consume more fresh fruits and vegetables. Lipid-lowering drug therapy, there are various contraindications, indications and adverse reactions, need to be under the guidance of a professional doctor, the rational use, while low-fat diet for the reduction of low-density lipoprotein, is also very important.