The difference between Zhi Bai Di Huang Wan and Jian Zi Li Zhong Wan lies in the composition, efficacy and main treatment. Composition: Zhi Bai Di Huang Wan consists of Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum (made from Cornu Cervi Pantotrichum), Rhizoma Dioscoreae, Rhizoma Dioscoreae, Poria, Ze Xie Di, Zhi Mu, and Cypress. Effects: Zhi Bai Di Huang Wan has the effect of nourishing yin and lowering fire (nourishing yin essence and lowering fire); Radix Rehmanniae Pill has the effect of warming the middle and strengthening the spleen. Indications: Zhi Bai Di Huang Wan is used for symptoms of yin deficiency and fire exuberance (deficiency of yin essence in the body, resulting in hyperactive fire), hot flashes (a burst of fever), night sweating (abnormal sweating after going to sleep, stopping sweating after waking up), dry mouth and sore throat, tinnitus, spermatorrhea, and urination with short and reddish urine (small amount of urine, dark yellow in color), while Fenzi Li Zhong Wan is used for symptoms of cold pain in epigastrium (cold and painful feeling in the epigastric region and the abdomen), and cold and loose stools (thin and unshapely feces). The adverse effects and contraindications of Zhi Bai Di Huang Wan and Hu Zi Li Zhong Wan are not known. If you need to use the medication, you should follow the doctor’s instructions under the guidance of the doctor, do not blindly self-medication.