Biological agents have the potential to produce side effects when administered, and symptoms vary from person to person. Biological agents used in the clinic include TNF-alpha inhibitors (e.g., infliximab for injection), anti-human CD20 monoclonal antibodies (e.g., rituximab injection), and interleukin-17A inhibitors (e.g., ezekizumab injection). Among them, infliximab for injection may cause users to experience side effects such as anemia, depression, headache, conjunctivitis, etc. It is contraindicated for patients with moderate-to-severe cardiac insufficiency and allergy to the drug. Rituximab injection may cause users to experience side effects such as neutropenia, angioedema, dizziness, tinnitus, and elevated blood glucose; it is contraindicated in patients who are allergic to mouse protein. Ezekizumab Injection may cause users to experience side effects such as upper respiratory tract infection, neutropenia, nausea, inflammatory bowel disease, skin eczema; active infectious diseases such as active tuberculosis, patients are prohibited from using it. The side effects of different biological agents on different human beings vary from person to person, and there is a certain correlation with the user’s individual physique, health status, etc., and these drugs are prescription drugs, their use must strictly follow the doctor’s instructions.