Treatment mainly starts from 3 aspects: 1st, stop all antipsychotic drugs; 2nd, give supportive symptomatic treatment, such as: oxygen, rehydration, correcting water and electrolyte disorders, lowering the temperature (because of the high fever of malignant syndrome is central hyperthermia, drug treatment is often ineffective, and it is best to use ice pillows, ice packs and other physical methods of lowering the temperature), anti-spasmodic, preventing infections; 3rd, the use of drugs to promote the function of the central dopamine – bromocriptine, the malignant syndrome, the treatment is best to choose the treatment in the Department of Critical Care Medicine.