How long it takes to heal on its own cannot be generalized, but needs to be determined in the context of the child’s specific condition. Most pediatric mesenteric lymphadenitis is caused by streptococcal or viral infections. For children with mild symptoms and in good general condition, no special treatment is needed. They can gradually heal themselves through dietary regulation, eating more vegetables and fruits, avoiding spicy and stimulating foods, and increasing exercise. However, how long it takes to heal itself varies depending on the individual’s constitution and diet, and there is no specific time for healing in clinical practice. If the symptoms do not improve in about 1 week, or if the disease is progressively aggravated, it is recommended to seek medical attention and carry out active anti-infection treatment. Otherwise, once an abscess or systemic infection appears, it will not only be more difficult to treat, but also life-threatening. In addition, there is a recurrence of mesenteric lymphadenitis in children after it has healed spontaneously, so children need to keep their abdomen warm and develop good habits on a daily basis.