Pediatric mesenteric lymphadenitis is a common pediatric disease, a self-limiting infectious disease that occurs in children under 7 years of age, often secondary to upper respiratory tract infections, intestinal infections, and mostly viral infections. Symptoms and treatment 1, symptoms: clinical manifestations of fever, abdominal pain, vomiting, similar to the symptoms of acute appendicitis. Before the onset of the disease, there are often prodromal symptoms such as sore throat, fever, tiredness and discomfort before the appearance of pain around the umbilicus and right lower abdomen, nausea, vomiting, and sometimes diarrhea or constipation can occur. The abdominal pain can be in any part, but because the lesion mainly invades a group of lymph nodes in the terminal ileum, the right lower abdominal pain is common; 2, treatment: most children can heal on their own without treatment. Children with more serious disease and combined bacterial infection can take antibiotics, such as cephalosporins, metronidazole, macrolides, etc., as prescribed by the doctor. If the symptoms of abdominal pain are more severe, appropriate antispasmodic and analgesic treatment can be administered. When mesenteric lymph node inflammation occurs, it needs to be differentiated from acute appendicitis to avoid the impact on the child’s health. In addition, during the treatment process, it is necessary to ensure a light diet and prohibit the consumption of cold, greasy or spicy stimulating foods to prevent further aggravation of symptoms.