Severe chronic atrophic gastritis and erosion with enterosis, if accompanied by Helicobacter pylori infection, need to carry out eradication treatment, if not accompanied by Helicobacter pylori infection, symptomatic treatment, maintain a healthy lifestyle, regular review. Severe chronic atrophic gastritis and erosion with enterosis are benign gastric mucosal lesions, mainly due to the reduction of intrinsic glands in the gastric mucosa, part of the glands intestinal epithelial metaplasia, losing the function of gastric mucosal glands, and at the same time the erosion refers to the localized active inflammation, and the treatment should be based on the presence or absence of Helicobacter pylori infection and the symptoms of the treatment method. Severe chronic atrophic gastritis accompanied by Helicobacter pylori infection, then the treatment is first to eradicate Helicobacter pylori, taking four drugs, an acid suppressant, a gastric mucosal protector, two antibiotics, usually for two weeks, and then recheck. When severe chronic atrophic gastritis is not accompanied by H. pylori infection, symptomatic treatment is the mainstay. If symptoms such as bloating, acidity and stomach pain occur, acid suppressants such as omeprazole and gastric mucosal protectants such as colloidal bismuth pectin can be taken to relieve the symptoms. If there is no symptom, no medication can be used, and regular review of gastroscopy is sufficient. Patients should pay attention to maintain a healthy lifestyle, eat a light diet, have regular meals, quit smoking and drinking, and maintain emotional stability, which can help prevent the progression of lesions. Treatment and medication need to follow the doctor’s instructions.